CHEMISTRY AND BIOCHEMISTRY: COURSE DESCRIPTIONS All courses listed will not necessarily be offered each year. The prerequisite of all 200-level courses, unless otherwise indicated, will be both 59-140 and 59-141. The prerequisite for all 400-level courses will be the consent of the instructor, except as noted. 59-110. Topics In General Chemistry An introduction to selected topics in modern chemistry for science and engineering: properties of matter and solutions, stoichiometry, equilibrium theory and applications, oxidation-reduction reactions, rate processes, atomic and molecular structure. (Prerequisite: OAC Chemistry or Grade 12 “U” Chemistry.) (3 lecture, 3 laboratory hours a week.) 59-140. General Chemistry I Introductory concepts in chemistry, including reactions of atoms, ions, and molecules, solution stoichiometry, thermochemistry, electronic structure of atoms, basic chemical bonding and molecular geometry, periodic properties of the elements, and the theory of gases. (Prerequisite: OAC Chemistry or Grade 12 “U” Chemistry or consent of the instructor.) (3 lecture, 3 laboratory/tutorial hours a week.) 59-141. General Chemistry II A continuation of 59-140 covering topics such as chemical kinetics, general equilibrium theory, acid-base theory, chemical thermodynamics, and introduction to organic chemistry. (Prerequisite: 59-140.) (3 lecture, 3 laboratory/tutorial hours a week.) 59-191. Organic and Biological Chemistry for Health Sciences A course of particular interest to students of nursing and other health science areas. The subject matter includes a survey of organic functional groups, the organic chemistry of biomolecules, and a survey of the major metabolic pathways. (Prerequisite: OAC Chemistry or Grade 12 “U” Chemistry.) (Antirequisites: 59-141, 59-230, and 59-232.) (2 lecture hours, 1 tutorial hour a week.) 59-201. Chemistry in the Marketplace The basic notions of chemistry will be introduced and discussed in a qualitative manner with a view to understanding chemistry and materials encountered in everyday life. The course will provide an appreciation for the ubiquitous nature and importance of chemicals and chemical processes. Discussion will include a variety of topics such as chemistry in the home, plastics, drugs, cosmetics, biotechnology, chemistry and computer technology, nuclear power and pollution. The course is intended for students with no formal background in chemistry. (Not open to first-year students; may be taken by B.Sc. students for credit, but it does not count as Chemistry and Biochemistry course or other science option towards the fulfillment of the requirements for the B.Sc. degree.) (2 lecture hours a week). 59-230. Introductory Organic Chemistry Introduction to organic chemistry, with emphasis on structure, stereochemistry, and reactions of aliphatic and alicyclic compounds and their functionalized derivatives. (Prerequisites: 59-140 and 59-141, or 59-110.) (Antirequisite: 59-232.) (3 lecture, 3 laboratory hours a week.) 59-232. Introductory Organic Chemistry The same as 59-230 but without the laboratory. (Prerequisites: 59-140 and 59-141.) (Antirequisite: 59-230.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.) 59-235. Introductory Organic Chemistry II A continuation of 59-230. Topics include the chemistry of nitrogen-containing compounds, aromatic chemistry and an introduction to spectroscopic methods. (Prerequisite: 59-230.) (2 lecture hours a week.) 59-240. Introductory Physical Chemistry I Properties of ideal and real gases, first and second laws of thermodynamics, physical transformations of substances, mixtures of substances and phase diagrams are applied to changes of state, chemical reactions and spontaneous processes. (Prerequisites: 59-141, 62-140, and 62-141.)(3 lecture, 1.5 tutorial hours per week.) 59-241. Introductory Physical Chemistry II Physical and chemical equilibrium, equilibrium electrochemistry, molecular motion and collisions, chemical reaction rates, kinetics and introduction to statistical mechanics. (Prerequisite: 59-240.) (3 lecture, 3 laboratory hours per week.) 59-250. Introductory Inorganic Chemistry I Introduction to inorganic chemistry. Topics include: the origin of trends in the periodic table, molecular symmetry, and chemical bonding (including ionic bonding and the molecular orbital and valence bond models for covalent bonding). These approaches will be used to explain the chemistry and properties of selected classes of main group compounds. Photoelectron, NMR, and vibrational spectroscopy are introduced as complementary tools in the examination of these molecular species. (Prerequisite: 59-141) (3 lecture hours a week.) 59-251. Introductory Inorganic Chemistry II The coordination chemistry of transition metals will be discussed, with particular reference to the means of physical and spectroscopic characterization. Relevance of such compounds to bio-inorganic systems will also be discussed. (Prerequisite: 59-250.) (3 lecture, 3 laboratory hours a week.) 59-253. Introductory Inorganic Chemistry II The same as 59-251 but without the laboratory. (Prerequisite: 59-250 and consent of instructor.) (3 lecture hours a week.) 59-261. Organic Chemistry of Biomolecules An extension of the principles covered in 59-230 to the structure and properties of organic molecules of biological significance. i.e., proteins, nucleic acids and lipids. (Prerequisite: 59-230.) (3 lecture, 3 laboratory hours a week.) 59-263. Organic Chemistry of Biomolecules The same as 59-261 but without the laboratory. (Prerequisites: 59-230 or 59-232 or consent of instructor.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.) 59-291. Pharmacology for Health Sciences A course of particular interest to students of nursing and other health science areas. The principles of pharmacokinetics and pharmacodynamics will be covered utilizing a systems approach to pharmacologic therapies in health care. (Prerequisites: 55-204, 55-205, and one of 59-191, 59-261 and 59-263.) (3 lecture hours a week, 4 tutorial hours in a semester.) (May be taken by B.Sc. students for credit, but does not count as a Biochemistry course towards the fulfillment of the requirements for the B.Sc. degree.) 59-320. Analytical Chemistry Fundamental chemical principles and theory that are important to classical, or "wet" analytical chemistry are presented, and illustrated using practical applications. The topics covered in this course include aqueous-solution chemistry, equilibria in complex systems, electrolytes, and titrimetric methods of analysis (gravimetric, precipitation, acid-base, complexiometric and reduction-oxidation). Theory and applications of electrochemical techniques include potentiometric and amperometric titrations. (Prerequisite: 59-141 or consent of instructor.) (3 lecture hours, 3 laboratory hours a week.) 59-321. Principles of Instrumental Analysis The fundamental principles of operation and practical application of modern analytical instrumentation are presented. Acquisition of qualitative and quantitative chemical, biochemical and bioanalytical data from these instruments and methods describes the atomic and molecular composition and structure of matter. Topics covered in this course include atomic and molecular absorption and emission (photoluminescence) spectroscopy, atomic and molecular mass spectroscopy, and separation methods such as gas and liquid chromatography and capillary electrophoresis. (Prerequisite: 59-320 or consent of instructor.) ( 3 lecture, 3 laboratory hours a week.) 59-330. Spectroscopic Structure Identification Structure elucidation and the use of spectroscopic techniques in synthetic chemistry. The experimental and theoretical principles of mass spectrometry, UV/visible, infrared and nucliear magnetic resonance spectroscopy, with focus on applications of spetroscopic techniques to structure analysis. (Prerequisite: 59-235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 59-331. Intermediate Organic Chemistry The methods of organic synthesis and the reaction mechanisms involved. (Prerequisite: 59-235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 59-332. Spectroscopic Structure Identification The same as 59-330 but without the laboratory. (Prerequisite: 59-235 or consent of instructor.) (3 lecture hours a week.) 59-333. Intermediate Organic Chemistry The same as 59-331 but without the laboratory. (Prerequisite: 59-235 or consent of instructor.) (3 lecture hours a week.) 59-340. Quantum Chemistry Principles of quantum theory, origins of quantum mechanics, wave-particle duality, Schroedinger equation, Born interpretation of the wavefunction, the uncertainty principle, applications of quantum mechanics, atomic structure and spectra, molecular structure, molecular orbital theory, introduction to computational chemistry. (Prerequisite: 59-241.) (3 lecture, 3 laboratory hours per week.) 59-341. Molecular Spectroscopy Symmetry elements, group theory, character tables, rotational and vibrational spectroscopy, electronic transitions, lasers, photoelectron spectroscopy, introduction to nuclear magnetic resonance, electron spin resonance. (Prerequisite: 59-340 or consent of instructor.) (3 lecture, 3 laboratory hours per week.) 59-342. Quantum Chemistry The same as 59-340 but without laboratory. (Prerequisite: 59-241 and consent of instructor.) (3 lecture hours a week.) 59-343. Molecular Spectroscopy The same as 59-341 but without the laboratory. (Prerequisite: 59-340 or 59-342 and consent of instructor.) (3 lecture hours a week.) 59-350. Organometallic Chemistry This course provides an introduction to the organometallic chemistry of the transition metals. (Prerequisite: 59-251 or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 59-351. Materials Chemistry Modern topics in materials science and solid state chemistry are discussed with an emphasis on properties, applications, and methods of characterization. The areas covered will include biometric materials, nanoscale engineering, liquid crystals, semiconductors, superconductors, organic metals, ferromagnetism and the ferroelectric effect, non-linear optical materials, thermochromic solids, scanning tunneling microscopy, and atomic force microscopy. Emphasis on applications to biomaterials engineering. (Prerequisite: 59-251.) (3 lecture hours a week.) 59-352. Intermediate Inorganic Chemistry The same as 59-350 but without the laboratory. (Prerequisite: 59-251 and consent of instructor.) (3 lecture hours a week.) 59-360. Metabolism I Catabolism and the generation of phosphate bond energy. Laboratory exercises are associated with the analytical and preparative procedures of biochemistry. (Prerequisite: 59-261.) (3 lectures, 3 laboratory hours a week.) 59-361. Metabolism II The utilization of phosphate bond energy will be illustrated by carbohydrate, fatty acid and lipid biosynthesis, hormonal (G-proteins) and metabolite regulation, biological membranes (structure and transport mechanisms) and contractile processes (muscle biochemistry). (Prerequisite: 59-360.) (2 lectures hours a week, 6 laboratory hours per week on alternate weeks.) 59-362. Metabolism I The same as 59-360 but without the laboratory. (Prerequisite: 59-261 or 59-263.) (3 lecture hours a week.) 59-363. Metabolism II The same as 59-361 but without the laboratory. (Prerequisite: 59-360 or 59-362.) (2 lecture hours a week.) 59-365. Protein and Nucleic Acid Chemistry The covalent and three dimensional structures of these macromolecules will be described in conjunction with study of the chemical and physical methods used in their purification and characterization. (Prerequisite: 59-261.) (2 lecture hours a week.) 59-380. Biotechnology Internship I A laboratory course focusing on the basic techniques of biotechnology as applied to aspartate transcarbamylase, an enzyme. Laboratory experiments will include DNA/plasmid isolation, probing its molecular genetics, protein isolation and characterization, and determining its enzymatic catalysis and regulation. (Prerequisite: 59-261, Corequisites: 59-360, 59-361 and 59-365.) (6 laboratory hours on alternate weeks over two terms, 6.0 credit hours.) 59-400. Seminar Discussion of selected topics from the current literature. (1 lecture hour a week over two terms; 3.00 credit hours; under special circumstances may be completed in one term.) (Normally open to students in only Chemistry Honours, Chemistry and Physics Honours, or Biochemistry Honours.) 59-410. Research Original laboratory research under the direction of a faculty member. (1 lecture, 12 laboratory hours a week) (A 6.00 credit hour course given over two terms.) (See above, "Program Requirements".) 59-421. Advanced Analytical Chemistry Special topics in analytical chemistry. (2 lecture hours a week.) 59-431. Special Topics in Organic Chemistry Topics may include polymer chemistry, natural product chemistry, advanced synthetic methodology, or design and execution of organic syntheses. (Prerequisite: 59-331 or consent of instructor.) (2 lecture hours a week.) This course may be repeatable for credit. 59-435. Advanced Organic Chemistry Physical organic chemistry. Includes molecular orbital theory, stereochemistry, thermodynamics, and reaction mechanisms. (Prerequisite: 59-331 or consent of instructor.) (2 lecture hours a week.) 59-440. Kinetics and Photochemistry Rates of reaction, theory and mechanisms, solution kinetics and photochemical kinetics. (2 lecture hours a week.) 59-441. Statistical Thermodynamics This course covers the following topics: laws of thermodynamics, heat capacities, distribution laws, partition functions, and chemical equilibria and kinetics. The subject will be further illuminated by discussions of low temperature phenomena and spectroscopy. (Prerequisite: 59-241.) (3 lecture hours a week.) 59-445. Advanced Physical Chemistry Special topics in physical chemistry. (2 lecture hours a week.) 59-450. Special Topics in Main Group Chemistry This course provides and introduction to the chemistry of main group elements with a particular focus on the elements of the p-block. The material will highlight the similarities and differences observed between organic molecules and those from the rest of the periodic table with respect to their structural features, bonding and reactivity. (Prerequisite: 59-250.) (3 lecture hours a week.) 59-451. Special Topics in Inorganic Chemistry Advanced topics in inorganic chemistry and organometallic chemistry may include analytical and spectroscopic methods of use to the inorganic chemist, advanced topics in main group chemistry, coordination chemistry, organometallic chemistry, or the chemistry of the lanthanides and actinides. (Prerequisite: 59-351 or consent of instructor.) (2 lecture hours a week.) This course may be repeatable for credit. 59-464. Enzymology Mechanisms of enzyme action will be covered in terms of kinetics, functional groups responsible for catalysis and specificity and the design of active-site directed irreversible inhibitors. (2 lecture hours a week.) 59-466. Drug Design Lectures cover various aspects of drug discoveries and designs. Beginning with basic knowledge in pharmacokinetics and pharmacodynamics, students should learn how lead is discovered and how the lead is modified to yield potent therapeutic agents. Several techniques in the area of molecular biology, biochemistry, organic chemistry and computational biology will be discussed and presented. (Prerequisite: 59-261.) (2 lecture hours per week.) 59-468. DNA Science and Diagnostics An advanced lecture dealing with DNA science and the application of DNA technology in the understanding and diagnosis of human disease. The lectures cover the biochemistry and expression of DNA and RNA at the molecular level, the theory and practice of recombinant DNA technology, and the application of DNA probes in diagnosis of human disease and in human gene therapies. (Prerequisite: 59-365.) (2 lecture hours per week.) 59-470. Introduction to Computational Chemistry Students are introduced to modern methods in computational chemistry, including semi-empirical techniques, ab initio calculations, molecular mechanics, and biomolecular modelling. Course emphasis is upon the physical basis of these techniques and their application in chemical research. Practical instruction in modelling and graphical software will be given, and assignments and projects will be computer based. (Prerequisite: 59-241.) (3 lecture, 2 laboratory hours per week.) 59-476. Special Topics in Chemistry (2 lecture hours a week.) (this course is repeatable for credit.) 59-480. Bioinformatics/Genomics/Proteomics Introduction to informatics, flow of genetic information from nucleic acid sequence to amino acid sequence, gene expression profiling at the mRNA level, gene micro arrays, application of genomic database (Swissprot, gene bank). Introduction to functional genomics, proteomics, protein profiling, 2D gel electrophoresis, mass spectrometry of proteins eluted from 2D gels, peptide mass fingerprinting, comparative proteome analysis, application of 2D protein database and MS peptide database, high throughput analysis of protein-protein interactions, antibodies and phage-display technologies for protein micro array analysis. (Prerequisite: 59-365.) (2 lecture hours per week.)